Senamile began her career as a Graduate Teaching Assistant at the University of KwaZulu-Natal, where she provided academic support to law students, facilitated tutorials, and coordinated the Moot Court competition.

She went on to complete her Practical Vocational Training at Livingston Leandy Incorporated, specialising in general litigation with a focus on foreclosures, family law, and debt recovery. Her contributions to the foreclosure team were recognised when the team won the Nedbank Regional Award (2023–2024).

In 2025, Senamile joined Cox Yeats Attorneys as an Associate, where she advises and represents clients in construction disputes, contractual claims, and general litigation. She is actively involved in drafting pleadings, opinions, and correspondence for High Court matters, while also engaging in settlement negotiations, mediation, and alternative dispute resolution. Awards and Accolades